Spectrophotometric determination of nimesulide by oxidative coupling with N-bromosuccinimide and promethazine hydrochloride

Nagaraja, P. and Arun Kumar, H. R. and Vasantha, R. A. and Yathirajan, H. S. (2003) Spectrophotometric determination of nimesulide by oxidative coupling with N-bromosuccinimide and promethazine hydrochloride. OXIDATION COMMUNICATIONS, 26 (1). pp. 116-120.

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Abstract

Rapid, sensitive and simple spectrophotometric method for the determination of nimesulide (NIME) is described. The method is based on the oxidation of promethazine hydrochloride (PMH) by N-bromosuccinimide (NBS) to give a radical cation, which is coupled with reduced nimesulide to produce a green product which has a)lambda(max) of 610 nm and is stable for three days. Beer's law is obeyed in the concentration range of 0.4 - 8.0 mug ml(-1). The method is successfully employed for the determination of nimesulide in pharmaceutical preparations and common excipients used as additives in pharmaceuticals do not interfere in the proposed method. A suitable reaction mechanism is proposed for the product formation.

Item Type: Article
Uncontrolled Keywords: nimesulide; N-bromosuccinimide; promethazine hydrochloride; oxidation; coupling; pharmaceuticals
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Users 11 not found.
Date Deposited: 15 Apr 2013 05:00
Last Modified: 29 Aug 2013 11:17
URI: http://eprints.uni-mysore.ac.in/id/eprint/4464

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