Pseudo-peptides as novel antileptospiral agents: Synthesis and spectral characterization

Shivamallu, C. and Sharanaiah, U. and Kollur, S. P. and Mallesh, N. K. R. and Hosakere, R. D. and Balamurugan, V. (2014) Pseudo-peptides as novel antileptospiral agents: Synthesis and spectral characterization. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 118. pp. 1152-1157.

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Official URL: https://doi.org/10.1016/j.saa.2013.09.105

Abstract

In this paper, we describe the synthesis of novel class of pseudo-peptides derived by coupling an amino acid with a heterocyclic moiety containing free amine group using suitable coupling agents. The synthesized compounds were characterized using spectral (1H NMR, 13C NMR and MS) techniques. Preliminary pharmacological assays for Leptospirosis were studied by test tube dilution (TDT) and micro dilution technique (MDT). In particular, all the analyses led to the conclusion that the synthesized compound inhibiting the Leptospira a causal organism of Leptospirosis.

Item Type: Article
Uncontrolled Keywords: human, Spectroscopic technique, chemical structure, chemistry, Humans, synthesis, drug effect, Anti-Bacterial Agents, antiinfective agent, Nuclear magnetic resonance spectroscopy, article, minimum inhibitory concentration, Peptides, Leptospira, leptospirosis, Leptospirosis, Spectrum analyzers, Amino acids, Models, Molecular, Minimum inhibitory concentration, drug derivative, Tryptophan, tryptophan, Anti-leptospiral activity, Coupling agents, Dilution technique, Free amines, Heterocyclic moieties, peptidomimetic agent, Peptidomimetics, Pseudo-peptide, Spectral characterization, Test tube
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Divisions: Department of > Biotechnology
Department of > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 14 Jul 2019 10:02
Last Modified: 14 Jul 2019 10:02
URI: http://eprints.uni-mysore.ac.in/id/eprint/4430

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