Safety evaluation of artocarpus altilis as pharmaceutical agent in wistar rats

Sairam, S. and Asna Urooj (2014) Safety evaluation of artocarpus altilis as pharmaceutical agent in wistar rats. Journal of Toxicology, 2014.

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This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg-1 BW). The extracts (ALA, ABA, ALM, and ABM) did not cause any behavioural or physical changes in experimental rats. There was no significant (P�0.05) difference in the biochemical parameters analysed between the groups. Slight elevation in activities of AST and ALT in extract treated groups was observed, but this did not exert any deleterious effect on the normal metabolism which was supported by the histopathology of liver. Histopathological studies showed no remarkable changes after 14 days of oral administration of ALA, ABA, ALM, and ABM extracts. The study contributes to establishing the nontoxic quality parameters of Artocarpus altilis leaf and bark parts and the results suggest the safety of the extracts in therapeutic uses.

Item Type: Article
Uncontrolled Keywords: animal experiment, controlled study, nonhuman, unclassified drug, adult, animal tissue, rat, Wistar rat, histopathology, plant extract, article, biochemistry, bark, alanine aminotransferase, alanine aminotransferase blood level, aspartate aminotransferase, aspartate aminotransferase blood level, plant leaf, drug safety, Artocarpus altilis extract, breadfruit, acute toxicity, liver histology
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 21 Aug 2019 06:43
Last Modified: 21 Aug 2019 06:43

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