Radical scavenging and angiotensin converting enzyme inhibitory activities of standardized extracts of ficus racemosa stem bark

Ahmed, F. and Siddesha, J. M. and Asna Urooj and Vishwanath, B. S. (2010) Radical scavenging and angiotensin converting enzyme inhibitory activities of standardized extracts of ficus racemosa stem bark. Phytotherapy Research, 24 (12). pp. 1839-1843. ISSN 0951-418X

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Official URL: https://dx.doi.org/10.1002/ptr.3205

Abstract

The present study evaluated the radical scavenging and angiotensin converting enzyme (ACE) inhibitory activity of cold and hot aqueous extracts of Ficus racemosa (Moraceae) stem bark. The extracts were standardized using HPLC. Radical scavenging activity was determined using 1,1-diphenyl-2-picrylhydrazyl radical and angiotensin converting enzyme inhibitory activity using rabbit lung and partially purified porcine kidney ACE. HPLC profiles of cold aqueous extract (FRC) showed the presence of bergenin, an isocoumarin, while hot aqueous extract (FRH) was found to contain ferulic acid, kaempferol and coumarin in addition to bergenin. FRH showed significantly higher (p <= 0.01) radical scavenging activity than FRC and butylated hydroxytoluene (BHT), consequently resulting in a significantly lower (p <= 0.01) IC(50), value than FRC and BHT. Both the extracts exhibited a dose dependent inhibition of porcine kidney and rabbit lung ACE. FRH showed significantly higher (p <= 0.01) activity than FRC with lower IC(50) values of 1.36 and 1.91 mu g/mL respectively, for porcine kidney and rabbit lung ACE, compared with those of FRC (128 and 291 mu g/mL). Further, a significant correlation (r = 0.893; p <= 0.05) was observed between radical scavenging activity and ACE-inhibitory activity. This is the first report on the ACE-inhibitory activity of F. racemosa stem bark suggesting its potential to be utilized as a therapeutic alternative for hypertension. Copyright (C) 2010 John Wiley & Sons, Ltd.

Item Type: Article
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: lpa manjunath user
Date Deposited: 29 Jun 2019 11:49
Last Modified: 17 Dec 2019 11:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/4172

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