In vitro hypoglycemic effects of Butea monosperma Lam. Leaves and bark

Harish, M. and Ahmed, F. and Asna Urooj (2014) In vitro hypoglycemic effects of Butea monosperma Lam. Leaves and bark. Journal of Food Science and Technology, 51 (2). pp. 308-314. ISSN 0022-1155

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Official URL: https://doi.org/10.1007/s13197-011-0496-8

Abstract

The present study evaluated the antidiabetic potential of Butea monosperma Lam. Kuntze (Fabaceae) leaves and the stem bark using various in vitro techniques. The samples were studied for their effects on glucose adsorption, diffusion, amylolysis kinetics, enteric enzymes and glucose transport across yeast cells. Both the samples adsorbed glucose and the adsorption of glucose increased with increase in glucose concentration. The samples also inhibited movement of glucose across the dialysis membrane to varying degree in both glucose diffusion and amylolysis kinetic experiment models. B. monosperma leaves inhibited α-amylase, α-glucosidase and sucrase enzymes in succession to varying degrees, whereas the bark inhibited only α-amylase to a significant extent and slightly activated α-glucosidase and sucrase enzymes. The extracts of both leaves and bark promoted glucose uptake by yeast cells compared to control. Enhancement of glucose uptake was dependent on both the sample and glucose concentration. It was directly proportional to the sample concentration and inversely proportional to the molar concentration of the glucose. From the results of the study, it is inferred that, B. monosperma leaves and bark possesses antidiabetic activity. However, these effects need to be confirmed using in vivo models and clinical trials for its effective utilization as therapeutic agents.

Item Type: Article
Uncontrolled Keywords: Adsorption, Plants (botany), Glucose, Butea monosperma, Starch, Fabaceae, Amylases, Dialysis membranes, GDRI, Glucose uptake, Glucosidase, Sucrase, Yeast
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Arshiya Kousar
Date Deposited: 21 Jun 2019 05:54
Last Modified: 23 Aug 2019 07:12
URI: http://eprints.uni-mysore.ac.in/id/eprint/3495

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