Inhibitory Potency of C-glycosyl Flavonoids from Morus sp. on advanced Glycation end products

Anandan, S. and Namratha Pai, K. and Lohith, M. S. and Urooj, Asna (2017) Inhibitory Potency of C-glycosyl Flavonoids from Morus sp. on advanced Glycation end products. Journal of Biologically Active Products from Nature, 7 (5). pp. 391-400. ISSN 2231-1874

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Official URL: https://doi.org/10.1080/22311866.2017.1398680

Abstract

Advanced glycation end products (AGEs) formation is associated with different pathophysiological conditions, including diabetes mellitus. Our study aimed at screening the effect of 80 % aqueous methanol extract of leaves (AQME) of three commercial varieties of Morus indica (G4, V1 and S36) and two wild varieties of Morus sp., (Morus laevigata - ML and Morus serrata-MS) on in vitro protein glycation in BSA-glucose model. G4 exhibited the highest AGEs inhibition and metal ion chelation. It also inhibited cross-linking of protein glycation and protein aggregation. The G4 extract had a total polyphenol content of 96 mg GAE g-1 and flavonoid content of 55.3 mg CE g-1. C-glycosyl flavonoids were identified and quantified in G4 by UPLC/MS. This is the first study reporting the presence of luteolin (258 μg g-1) and apigenin (164 μg g-1) in G4 variety which possess the most active anti-glycation property. Thus, G4 could be protective against hyperglycemia-mediated protein damage.

Item Type: Article
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: MUL SWAPNA user
Date Deposited: 18 Jun 2019 10:27
Last Modified: 04 Jul 2019 10:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/3364

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