DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization

Naik, K. H. K. and Ashok, B. and Naik, N. and Mulla, J. A. S. and Prakasha, A. (2015) DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 141. pp. 88-93. ISSN 1386-1425

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Official URL: https://doi.org/10.1016/j.saa.2014.11.068

Abstract

Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like M(AMTA)(2)], M(ATA)(2)] type, where M = Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium. (C) 2014 Elsevier B.V. All rights reserved.

Item Type: Article
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Divisions: Department of > Biotechnology
Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 11 Jun 2019 09:24
Last Modified: 11 Jun 2019 09:24
URI: http://eprints.uni-mysore.ac.in/id/eprint/2743

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