Hepatoprotective effect of Artocarpus altilis (Parkinson) fosb.leaf and bark extracts against CCl4 induced hepatic damage in albino rats

Sudha Sairam and Asna Urooj and Sreenivas, N. (2016) Hepatoprotective effect of Artocarpus altilis (Parkinson) fosb.leaf and bark extracts against CCl4 induced hepatic damage in albino rats. Annals of Phytomedicine, 5 (1). pp. 80-84. ISSN 2393-9885

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Abstract

Medicinal plants and their formulations are being used from thou sands of years in traditionalmedicine worldwide. Numerou s plants and polyherbal formulations are u sed for treatment ofhepatic diseases. In the present study, the hepatoprotective effect of aqu eous and 80% methanolextracts of Arto carpus a ltilis (Parkinson) Fosb. leaf (ALAE, ALM80) and bark (ABAE, ABM80)were stu died in rats with hepatotoxicity induced by carbon tetra chloride (CCl4) and comparedwith standard dru g (Liv52 ) and untreated groups (CCL4). Activity of aspartate aminotransferase(AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and selected biochemicalparameters were estimated in serum. Glu tathione (GSH) content and lipid peroxidation (TBARS)were analysed in serum, liver and kidney homogenates. The AST, ALT and ALP levels in extracttreated grou ps were significantly (p0 .0 5 ) lower than CCL4 group. Pretreatment with ALAE,ALM80, ABAE and ABM80 restored total protein and albumin to near normal levels. The extractsimproved the antioxidant status considerably as reflected by low TBARS and high GSH values. Theresu lt s indicate that A. a ltili s leaf and bar k extra ctspossess po tent h epatop rotect ive effectagainst CCl4-induced hepatic damage in rats.

Item Type: Article
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Manjula P Library Assistant
Date Deposited: 06 Jun 2019 09:59
Last Modified: 06 Jun 2019 09:59
URI: http://eprints.uni-mysore.ac.in/id/eprint/2679

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