In silico studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone on proteins AChE and BChE involved in alzheimer's disease and ameliorative effects on paraquat induced oxidative stress markers in drosophila melanogaster

Sarojini, B. K. and Raj, C. G. and Ramakrishna, M. K. and Ramesh, S. R. and Bharath, B. R. and Manjunatha, H. (2011) In silico studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone on proteins AChE and BChE involved in alzheimer's disease and ameliorative effects on paraquat induced oxidative stress markers in drosophila melanogaster. Letters in Drug Design & Discovery, 8 (3). pp. 260-267.

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Official URL: https://dx.doi.org/10.2174/157018011794578213

Abstract

In the present study, the ameliorative effect of a bischalcone (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone (CA), a curcumin analog was studied on Drosophila melanogaster (oregon K strain) in vivo by inducing oxidative stress using paraquat. Curcumin (CU) was taken as standard for studies. In negative geotaxis assay it was found that CA was able to rescue the flies significantly from deteriorating locomotor dysfunctions. A docking study for antialzeimer's activity of CA was carried out by targeting the proteins Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). It binds effectively to the target proteins.

Item Type: Article
Uncontrolled Keywords: Antioxidant; Alzheimer disease; Bischalcone; Paraquat; Molecular docking; Oxidative stress
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: lpa venkatesh user
Date Deposited: 21 Jun 2019 09:53
Last Modified: 11 Oct 2019 05:52
URI: http://eprints.uni-mysore.ac.in/id/eprint/2549

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