Amelioration of diabetes by swietenia mahagoni in streptozotocin induced diabetic rats

Naveen, Y. P. and Urooj, A. (2015) Amelioration of diabetes by swietenia mahagoni in streptozotocin induced diabetic rats. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 6 (9). pp. 3892-3900. ISSN 0975-8232

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Official URL: http://doi.org/10.13040/IJPSR.0975-8232.6(9).3892-...

Abstract

Sweitenia mahagoni is a natural medicine used to treat various human ailments including diabetes. The present study is a comprehensive approach which targets more than one locus in the diabetic model to enumerate the anti-diabetic potential of Swietenia mahagoni as claimed by folklore. Oral administration of the aqueous extract of the leaf decreased the fasting blood glucose level (155.2 +/- 6.7) from its initial value (309.8 +/- 10.5) in diabetic rats. There was improvement in the content of innate antioxidant components viz., glutathione (0.570 +/- 0.01) when compared to positive control group (0.28 +/- 0.02). The activity liver health marker enzymes in the serum were also decreased in the treated group compared to untreated diabetic group. There was also reduction in body mass loss in treated groups. Thus it can be proposed that Sweitenia mahagoni leaf has potent anti-diabetic activity and the effect may be mediated through increasing the antioxidant strength, improving glycogen content in liver, balancing the lipid components in serum, decreasing the muscle protein catabolism and improved overall health.

Item Type: Article
Uncontrolled Keywords: Sweitenia mahagoni; anti-diabetic; liver glycogen; hyperglycemia
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Shrirekha N
Date Deposited: 31 May 2019 09:39
Last Modified: 31 May 2019 09:39
URI: http://eprints.uni-mysore.ac.in/id/eprint/1003

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