Novel one-pot three-component synthesis of new ethyl 8-methyl-3,6-diphenyl-2,6-dihydropyrimido2,1-b 1,3,4thiadiazine-7-carboxylate derivatives and its antimicrobial activities

Shubakaraa, K. and Umeshaa, K. B. and Srikantamurthya, N. and Chethanb, J. (2014) Novel one-pot three-component synthesis of new ethyl 8-methyl-3,6-diphenyl-2,6-dihydropyrimido2,1-b 1,3,4thiadiazine-7-carboxylate derivatives and its antimicrobial activities. International Journal of Applied Biology and Pharmaceutical Technology, 5 (2). pp. 101-107. ISSN 0976-4550

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Abstract

A novel series of ethyl 8-methyl-3,6-diphenyl-2,6-dihydropyrimido2,1-b1,3,4-thiadiazine-7-carboxylates 4 (a-m) were synthesized in good to excellent yield via cyclocondensation of2-amino-5-pheny-6H-1,3,4-thiadiazine 1 (a-d) with ethyl acetoacetate (2) and various substituted aldehydes 3 (a-d) in presence of p-toluene sulfonic acid (PTSA) in acetonitrile. The structures of these compounds 4 (a-m) were characterized by IR, 1H NMR, 13C NMR, Mass spectroscopic techniques and elemental analysis. All newly synthesized compounds 4 (a-m) were screened for antimicrobial activities

Item Type:	Article
Uncontrolled Keywords:	One-Pot Three-Component Synthesis and 2-Amino-6H-1 and 3 and 4-Thiadiazines and PTSA and Antimicrobial.
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 19 not found.
Date Deposited:	12 Nov 2019 05:10
Last Modified:	12 Nov 2019 05:14
URI:	http://eprints.uni-mysore.ac.in/id/eprint/9956

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