Spectrophotometric determination of 4,4'-Sulphonyldianiline

Nagaraja, P. and Sunitha, K. R. and Yathirajan, H. S. and Vasantha, R. A. (2003) Spectrophotometric determination of 4,4'-Sulphonyldianiline. Indian journal of pharmaceutical sciences, 65 (1). p. 82. ISSN 1998-3743

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A simple, rapid and sensitive spectrophotometric method for the determination of 4,4'- sulphonyldianiline (dapsone) is described. The method is based on the formation of orange red coloured product by the diazotisation of dapsone followed by complexation with dopamine in presence of molybdate ions in 1:1 sulphuric acid medium. The product is stable for two days at 27o. Beer's law is obeyed in the concentration range of 0.1-8.0 μg/ml at 510 nm. The method is successfully employed for the determination of dapsone in tablets and common excipients used as additives in pharmaceuticals do not interfere. The method offers the advantages of simplicity,rapidity and sensitivity without the need for extraction or heating. Limit of detection and limit of quantification are reported.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 07 Nov 2019 05:53
Last Modified: 07 Nov 2019 05:53
URI: http://eprints.uni-mysore.ac.in/id/eprint/9869

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