Nagaraja, P. and Arun Kumar, H. R. and Vasantha, R. A. and Yathirajan, H. S. (2003) Spectrophotometric determination of nimesulide by oxidative coupling with N-bromosuccinimide and promethazine hydrochloride. Oxidation communications, 26 (1). pp. 116-120. ISSN 0209-4541
Full text not available from this repository. (Request a copy)Abstract
Rapid, sensitive and simple spectrophotometric method for the determination of nimesulide (NIME) is described. The method is based on the oxidation of promethazine hydrochloride (PMH) by N-bromosuccinimide (NBS) to give aradical cation, which is coupled with reduced nimesulide to produce a green product which has a λ m a x of 610 nm and is stable for three days. Beer's law is obeyed in the concentration range of 0.4-8.0 μg ml-1. The method is successfully employed for the determination of nimesulide in pharmaceutical preparations and common excipients used as additives in pharmaceuticals do not interfere in the proposed method. A suitable reaction mechanism is proposed for the product formation.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 07 Nov 2019 05:48 |
| Last Modified: | 07 Nov 2019 05:48 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/9868 |
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