Paliperidone: 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]eth­yl}-9-hy­dr­oxy-2-methyl-1,6,7,8,9,9a-hexa­hydro­pyrido[1,2-a]pyrimidin-4-one

Betz, Richard and Gerber, Thomas and Hosten, Eric and Dayananda, A. S. and Yathirajan, H. S. and Thomas, Saji (2011) Paliperidone: 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]eth­yl}-9-hy­dr­oxy-2-methyl-1,6,7,8,9,9a-hexa­hydro­pyrido[1,2-a]pyrimidin-4-one. Acta Crystallographica Section E, 67 (11). o2945-o2946. ISSN 2056-9890

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Abstract

The title compound (also known as 9-hy­droxy­risperidone), C23H27FN4O3, is a heterocyclic compound with manifold pharmacological properties. The hy­droxy group shows disorder over two positions, with site-occupancy factors of 0.856 (2) and 0.144 (2). The piperidine ring adopts a chair conformation, while the annulated ring bearing the hy­droxy group is present in a half-chair conformation. Classical O—H⋯O hydrogen bonds as well as C—H⋯N contacts connect the mol­ecules into undulating sheets lying perpendicular to the crystallographic b axis. The shortest centroid–centroid distance between two centers of gravity is 3.5867 (8) Å and is apparent between the benzoxazole moiety and the six-membered ring bearing the keto substituent.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	04 Nov 2019 09:45
Last Modified:	04 Nov 2019 09:45
URI:	http://eprints.uni-mysore.ac.in/id/eprint/9790

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