Redetermination of di­hydro­artemisinin at 103 (2) K

Jasinski, Jerry P. and Butcher, Ray J. and Yathirajan, H. S. and Narayana, B. and Sreevidya, T. V. (2008) Redetermination of di­hydro­artemisinin at 103 (2) K. Acta Crystallographica Section E, 64 (1). o89-o90. ISSN 2056-9890

[img] Text (Full Text)
Redetermination of di­hydro­artemisinin at 103 (2) K.pdf - Published Version

Download (425kB)
Official URL:


Tthe structure of the title compound, C15H24O5, has been redetermined at 103 (2) K, with much improved precision. The title compound was first reported by Luo, Yeh, Brossi, Flippen-Anderson & Gillardi [Helv. Chim. Acta (1984). 67, 1515–1522]. It is a derivative of the anti­malaria compound artemisinin and consists primarily of three substituted ring systems fused together. A cyclo­hexane ring (with a distorted chair conformation), is fused to a tetra­hydro­pyran group (also with a distorted chair conformation), and is adjacent to an oxacyclo­heptane unit containing an endoperoxide bridge. This gives the mol­ecule a unique three-dimensional arrangement. The crystal packing is stabilized by inter­molecular C–H⋯O and O–H⋯O inter­actions between an H atom from the cyclo­hexane ring and an O atom from the endoperoxide bridge, as well as between the hydroxyl H atom and an O atom from a tetra­hydro­pyran ring.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 02 Nov 2019 06:00
Last Modified: 02 Nov 2019 06:00

Actions (login required)

View Item View Item