Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era

Chandra Mohana, N. and Rao, H. C. Yashavantha and Rakshith, D. and Mithun, P. R. and Nuthan, B. R. and Satish, S. (2018) Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era. Journal of Genetic Engineering and Biotechnology, 16 (1). 1 - 8. ISSN 2090-5920

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Official URL: https://doi.org/10.1016/j.jgeb.2018.01.006

Abstract

The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which is considered treasure trove, there is re-emerged interest in exploring untapped microbial to yield novel molecules, due to their wide array of negative effects associated with synthetic drugs. Natural product researchers have developed many new techniques over the past few years for developing diverse compounds of biopotential. Taking edge in the advancement of genomics, genetic engineering, in silico drug design, surface modification, scaffolds, pharmacophores and target-based approach is necessary. These techniques have been economically sustainable and also proven efficient in natural product discovery. This review will focus on recent advances in diverse discipline approach from integrated Bioinformatics predictions, genetic engineering and medicinal chemistry for the synthesis of natural products vital for the discovery of novel antibiotics having potential application.

Item Type: Article
Uncontrolled Keywords: Genome mining, Genome shuffling, Metabolomics, Combinatorial synthesis and antibiotics
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: manjula User
Date Deposited: 25 Oct 2019 06:30
Last Modified: 25 Oct 2019 06:33
URI: http://eprints.uni-mysore.ac.in/id/eprint/9696

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