Synthesis of quinazolinone conjugated shorter analogues of bactenecin7 as potent antimicrobials

Suhas, R. and Chandrashekar, S. and Anil, S. M. and Gowda, D. C. (2013) Synthesis of quinazolinone conjugated shorter analogues of bactenecin7 as potent antimicrobials. Protein and Peptide Letters, 20 (2). pp. 146-155.

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Official URL: http://doi.org/10.2174/092986613804725235

Abstract

A series of shorter peptide analogues of Bactenecin7 (RP, PRP, GPRP and RPRP) were synthesized and conjugated to 3-(4-oxo-3,4-dihydroquinazolin-2-yl) propanoic acid to study the effect of conjugation. All the peptides and their conjugates were characterized by analytical and spectroscopic techniques. The synthesized compounds viz., peptides, heterocyclic conjugates and the hydrogenolyzed products were evaluated for antimicrobial activity against a panel of pathogens. The results revealed that all the conjugates have shown enhanced activity than their counterparts. Further, hydrogenolyzed tetrapeptide conjugates (10 and 13) have exerted highly potent activity nearly 3-4 times than the standard drugs used.

Item Type: Article
Uncontrolled Keywords: article, controlled study, drug screening, nonhuman, unclassified drug, antibacterial activity, antifungal activity, drug synthesis, antifungal agent, antiinfective agent, ciprofloxacin, drug potency, concentration response, drug conjugation, griseofulvin, 3 (4 oxo 3, 4 dihydroquinazolin 2 yl)propanoic acid bactenecin 7 derivative conjugate
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 30 Oct 2019 11:21
Last Modified: 30 Oct 2019 11:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/9676

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