Tandem approach for the synthesis of imidazo1,2-apyridines from alcohols

Ramesha, A. B. and Raghavendra, G. M. and Nandeesh, K. N. and Rangappa, K. S. and Mantelingu, K. (2013) Tandem approach for the synthesis of imidazo1,2-apyridines from alcohols. Tetrahedron Letters, 54 (1). pp. 95-100. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2012.10.112


Propylphosphonic anhydride (®T3P) is shown to be an effective and mild reagent for the one-pot synthesis of imidazo1,2-apyridines from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which in turn undergo a three-component reaction with various 2-aminopyridines and isocyanides to afford imidazo1,2-apyridines in excellent yields. ®T3P acts as an activator for both DMSO in oxidation reaction and the Schiff base in nucleophilic addition reaction with isocyanides.

Item Type: Article
Uncontrolled Keywords: article, unclassified drug, drug structure, dimethyl sulfoxide, oxidation, catalysis, proton nuclear magnetic resonance, one pot synthesis, propylphosphonic anhydride, aldehyde, Schiff base, alcohol derivative, nucleophilicity, 2 a]pyridine derivative, imidazo1, phosphonic acid derivative
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 30 Oct 2019 10:15
Last Modified: 30 Oct 2019 10:15
URI: http://eprints.uni-mysore.ac.in/id/eprint/9668

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