Cardioprotective effect of the root extract of Hemidesmus indicus against doxorubicin -Induced oxidative stress in mice

Zarei, M. and Javarappa, K. K. and Zarei, M. and Baker, S. (2013) Cardioprotective effect of the root extract of Hemidesmus indicus against doxorubicin -Induced oxidative stress in mice. Der Pharmacia Lettre, 5 (1). pp. 334-339.

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Abstract

The aim of this work was to investigate possible ameliorative action of Hemidesmus indicus root extract (HiRe) against doxorubicin (Dox) induced toxicity. HiRe was administered 14 days before doxorubicin (25 mg/kg.b.wt) administration. Mouse in all groups was sacrificed 24 hrs after doxorubicin injection. Serum markers of heart injury -LDH, CPK, SGOT and SGPT levels, which were markedly increased by doxorubicin treatment, were decreased to normal levels by HiRe pre-treatment. Antioxidant enzymes-SOD, CAT and GPx, as well as GSH levels in heart tissue decreased drastically after doxorubicin injection. HiRe pretreatment elevated these levels significantly. Oxidative stress markers in heart tissue, which were high in control animals, were decreased significantly by HiRe pretreatment. The biochemical changes were consistent with histopathological observations, suggesting that Hemidesmus indicus, due to its antioxidant properties significantly reduced the oxidative stress and thereby toxicity induced by doxorubicin.

Item Type: Article
Uncontrolled Keywords: alanine aminotransferase, alanine aminotransferase blood level, animal experiment, animal model, animal tissue, antioxidant activity, article, aspartate aminotransferase, aspartate aminotransferase blood level, cardiotoxicity, cardiovascular effect, catalase, controlled study, creatine kinase, creatine kinase blood level, glutathione, glutathione peroxidase, heart protection, Hemidesmus indicus extract, histopathology, lactate dehydrogenase, lactate dehydrogenase blood level, male, mouse, nonhuman, oxidative stress, plant root, superoxide dismutase
Subjects: B Life Science > Biotechnology
B Life Science > Environmental Science
B Life Science > Microbiology
Divisions: Department of > Biotechnology
Department of > Environmental Science
Department of > Microbiology
Depositing User: Arshiya Kousar
Date Deposited: 10 Dec 2019 05:49
Last Modified: 10 Dec 2019 05:49
URI: http://eprints.uni-mysore.ac.in/id/eprint/9634

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