SODs, DNA binding and cleavage studies of new Mn(III) complexes with 2-((3-(benzyloxy)pyridin-2-ylimino)methyl)phenol

Shivakumar, L. and Shivaprasad, K. and Revanasiddappa, H. D. (2013) SODs, DNA binding and cleavage studies of new Mn(III) complexes with 2-((3-(benzyloxy)pyridin-2-ylimino)methyl)phenol. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 107. pp. 203-212.

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Newly synthesized ligand 2-((3-(benzyloxy)pyridin-2-ylimino)methyl)phenol (Bpmp) react with manganese(II) to form mononuclear complexes Mn(phen)(Bpmp)(CH3COO)(H2O)·4H2O (1), (phen = 1,10-phenanthroline) and Mn(Bpmp)2(CH3COO)(H 2O)·5H2O (2). These complexes were characterized by elemental analysis, IR, 1H NMR, Mass, UV-vis spectral studies. Molar conductance and thermogravimetric analysis of these complexes were also recorded. The in vitro SOD mimic activity of Mn(III) complexes were carried out and obtained with good result. The DNA-binding properties of the complexes 1 and 2 were investigated by UV-spectroscopy, fluorescence spectroscopy and viscosity measurements. The spectral results suggest that the complexes 1 and 2 can bind to Calf thymus DNA by intercalation mode. The cleavage properties of these complexes with super coiled pUC19 have been studied using the gel electrophoresis method, wherein both complexes 1 and 2 displayed chemical nuclease activity in the absence and presence of H2O2 via an oxidative mechanism. All the complexes inhibit the growth of both Gram positive and Gram negative bacteria to competent level. The MIC was determined by microtiter method.

Item Type: Article
Uncontrolled Keywords: article, human, phenol derivative, 1, chemical structure, Animals, superoxide dismutase, Superoxide Dismutase, Fungi, antiinfective agent, Humans, DNA, animal, chemistry, 10-phenanthroline, Anti-Infective Agents, Anti-microbial activity, Bacteria, bacterium, Binding energy, Complexation, DNA binding, DNA cleavage, DNA Cleavage, DNA-binding properties, drug effect, Electrophoresis, Fluorescence spectroscopy, fungus, Gram-negative bacteria, metabolism, Mononuclear complexes, Spectroscopic analysis, Synthesis (chemical), Thermogravimetric analysis, Viscosity measurement, bacterial infection, Bacterial Infections, Models, Molecular, Phenols, Phenanthrolines, 10 phenanthroline, Manganese, phenanthroline derivative, Cattle, Mycoses, mycosis, Coordination Complexes, coordination compound, pyridine derivative, Pyridines, calf thymus dna, manganese, cattle, biomimetic material, Biomimetic Materials, DNA binding and cleavages, intercalating agent, Intercalating Agents, Oxidative DNA cleavages, Sod mimic activities
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 11 Nov 2019 05:59
Last Modified: 11 Nov 2019 05:59

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