Inhibition of in vitro TNF-α production by anisomeles malabarica R.Br. Reinforces its anti-rheumatic and immunomodulatory properties

Shareef, M. I. and Leelavathi, S. and Shariff, A. A. (2013) Inhibition of in vitro TNF-α production by anisomeles malabarica R.Br. Reinforces its anti-rheumatic and immunomodulatory properties. Proceedings of the National Academy of Sciences India Section B - Biological Sciences, 83 (2). pp. 187-191. ISSN 0369-8211

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Official URL: http://doi.org/10.1007/s40011-012-0128-8

Abstract

In-vivo studies have suggested the anti-rheumatic and immunomodulatory properties of the methanolic extract of the plant Anisomeles malabarica R.Br. However, the mechanism of action of this plant in the modulation of inflammation using the various in vitro models has not been explored earlier. Hence, the current investigation was undertaken to study the anti-rheumatic and immunomodulatory role of aerial parts, leaves and roots in lipopolysaccharide (LPS) mediated signaling in macrophage and mouse connective tissue cell cultures. It was observed from the present study that by employing tumor necrosis factor-α (TNF-α) bioassay, all the three extracts viz., aerial parts, leaves and roots inhibited TNF-α production in LPS (1 μg/mL) stimulated RAW-32 cells. 38.75 % inhibition of TNF-α was observed at 200 μg extracts of the aerial parts of the plant followed by 17.64 and 14.94 % by the roots and leaves respectively. Taken together, these findings from the present in vitro studies suggest the anti-rheumatic and immunomodulatory properties of the methanolic extracts of A. malabarica.

Item Type: Article
Subjects: B Life Science > Botany
Divisions: Department of > Botany
Depositing User: Arshiya Kousar
Date Deposited: 14 Nov 2019 05:35
Last Modified: 14 Nov 2019 05:35
URI: http://eprints.uni-mysore.ac.in/id/eprint/9609

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