Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice

Zarei, M. and Shivanandappa, T. (2013) Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice. Food and Chemical Toxicology, 57. pp. 179-184.

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Official URL: http://doi.org/10.1016/j.fct.2013.03.028

Abstract

Hepatoprotective potential of the aqueous extract of the roots of Decalepis hamiltonii (DHA) against cyclophosphamide (CP)-induced oxidative stress has been investigated in mice. Administration of CP (25. mg/kg b.w., i.p) for 10. days induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases (AST, ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Parallel to these changes CP induced oxidative stress in the liver as evident from the increased lipid peroxidation (LPO), reactive oxygen species (ROS), depletion of glutathione (GSH), and reduced activities of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST). Treatment with DHA (50 and 100. mg/kg b.w., po) mitigated the CP-induced oxidative stress. Moreover, expression of genes for the antioxidant enzymes, were down-regulated by CP treatment which was reversed by DHA. Our study shows the DHA protected the liver from toxicity induced by CP and therefore, it could be serve as a safe medicinal supplement during cyclophosphamide chemotherapy.

Item Type: Article
Uncontrolled Keywords: alanine aminotransferase, Alanine Transaminase, alkaline phosphatase, Alkaline Phosphatase, animal experiment, animal model, animal tissue, Animals, Antioxidants, Apocynaceae, article, aspartate aminotransferase, Aspartate Aminotransferases, catalase, Catalase, controlled study, cyclophosphamide, Cyclophosphamide, Decalepis hamiltonii, Decalepis hamiltonii extract, down regulation, drug safety, enzyme assay, enzyme inhibition, Enzymes, Enzymologic, gene expression regulation, Gene Expression Regulation, glutathione, glutathione peroxidase, Glutathione Peroxidase, glutathione reductase, Glutathione Reductase, glutathione transferase, Glutathione Transferase, lactate dehydrogenase, lipid peroxidation, Lipid Peroxidation, Liver, liver protection, liver protective agent, liver toxicity, male, Mice, mouse, Mus, nonhuman, oxidative stress, Oxidative Stress, plant extract, Plant Extracts, plant root, Plant Roots, Protective Agents, reactive oxygen metabolite, superoxide dismutase, Superoxide Dismutase, toxic hepatitis, unclassified drug, water
Subjects: B Life Science > Zoology
B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Department of > Zoology
Depositing User: Arshiya Kousar
Date Deposited: 16 Nov 2019 06:07
Last Modified: 16 Nov 2019 06:07
URI: http://eprints.uni-mysore.ac.in/id/eprint/9588

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