Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population

Venkatesh, S. K. and Siddaiah, A. and Padakannaya, P. and Ramachandra, N. B. (2013) Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population. Journal of Human Genetics, 58 (8). pp. 531-538. ISSN 1434-5161

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Developmental dyslexia (DD) is a heritable, complex genetic disorder associated with impairment in reading and writing skills despite having normal intellectual ability and appropriate educational opportunities. Chromosome 6p23-21.3 at DYX2 locus has showed the most consistent evidence of linkage for DD and two susceptible genes KIAA0319 and DCDC2 for DD at DYX2 locus showed significant association. Specific candidate gene-Association studies have identified variants, risk haplotypes and microsatellites of KIAA0319 and DCDC2 correlated with wide range of reading-related traits. In this study, we used a case-control approach for analyzing single-nucleotide polymorphisms (SNPs) in KIAA0319 and DCDC2. Our study demonstrated the association of DD with SNP rs4504469 of KIAA0319 and not with any SNPs of DCDC2.

Item Type: Article
Uncontrolled Keywords: Alleles, article, Case-Control Studies, child, Child, Dcdc2 gene, dyslexia, Dyslexia, female, Female, gene, Gene Frequency, gene locus, Genetic, genetic analysis, genetic association, Genetic Association Studies, Genetic Predisposition to Disease, genetic susceptibility, genetic variability, Genetic Variation, haplotype, human, Humans, India, Indian, Kiaa0319 gene, major clinical study, male, Male, Microtubule-Associated Proteins, Models, Nerve Tissue Proteins, Neuropsychological Tests, Polymorphism, population genetics, Preschool, Reading, Single Nucleotide, single nucleotide polymorphism
Subjects: A Arts and Humanities > Psychology
B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 18 Nov 2019 06:23
Last Modified: 18 Nov 2019 06:23

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