Family-based genome-wide copy number scan identifies five new genes of dyslexia involved in dendritic spinal plasticity

Veerappa, A. M. and Saldanha, M. and Padakannaya, P. and Ramachandra, N. B. (2013) Family-based genome-wide copy number scan identifies five new genes of dyslexia involved in dendritic spinal plasticity. Journal of Human Genetics, 58 (8). pp. 539-547. ISSN 1434-5161

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Official URL: http://doi.org/10.1038/jhg.2013.47

Abstract

Genome-wide screening for copy number variations (CNVs) in ten Indian dyslexic families revealed the presence of five de novo CNVs in regions harboring GABARAP, NEGR1, ACCN1, DCDC5, and one in already known candidate gene CNTNAP2. These genes are located on regions of chromosomes 17p13.1, 1p31.1, 17q11.21, 11p14.1 and 7q35, respectively, and are implicated in learning, cognition and memory processes through dendritic spinal plasticity, though not formally associated with dyslexia. Molecular network analysis of these and other dyslexia-related module genes suggests them to be associated with synaptic transmission, axon guidance and cell adhesion. Thus, we suggest that dyslexia may also be caused by neuronal disconnection in addition to the earlier view that it is due to neuronal migrational disorder.

Item Type: Article
Uncontrolled Keywords: accn1 gene, adolescent, Adolescent, adult, article, cell adhesion, child, Child, chromosome 11p, chromosome 17p, chromosome 17q, chromosome 1p, chromosome 7q, Chromosome Breakage, clinical article, CNTNAP2 gene, cognition, controlled study, dcdc5 gene, dendrite, Dendritic Spines, DNA Copy Number Variations, DNA polymorphism, dyslexia, Dyslexia, Family, female, Female, gabarap gene, gene, gene dosage, gene identification, Gene Ontology, Genetic, Genetic Predisposition to Disease, genetic screening, Genome-Wide Association Study, human, Humans, Indian, learning, male, Male, memory, NEGR1 gene, nerve cell differentiation, nerve cell plasticity, Neuronal Plasticity, Neuropsychological Tests, neurotransmission, Phenotype, Polymorphism, protein interaction, Protein Interaction Maps, Reproducibility of Results, school child, Signal Transduction, synaptic transmission, Young Adult
Subjects: A Arts and Humanities > Psychology
B Life Science > Zoology
Divisions: Department of > Psychology
Department of > Zoology
Depositing User: Arshiya Kousar
Date Deposited: 18 Nov 2019 06:19
Last Modified: 18 Nov 2019 06:24
URI: http://eprints.uni-mysore.ac.in/id/eprint/9577

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