Antitumor effect of decalepis hamiltonii root extract against ehrlich ascites tumor in mice

Zarei, M. and Shivanandappa, T. (2013) Antitumor effect of decalepis hamiltonii root extract against ehrlich ascites tumor in mice. International Journal of Pharma and Bio Sciences, 4 (3). pp. 88-96.

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Official URL: https://ijpbs.net/abstract.php?article=MjM5Ng==

Abstract

The antitumor activity of Decalepis hamiltonii root extract (DHA) was investigated in Ehrlich Ascites Tumor (EAT) cell model in mice and the effect was compared with that of the anticancer drug, cyclophosphamide (CP). Treatment of EAT cell bearing mice with aqueous extract of Decalepis hamiltonii (50 mg/kg and 100 mg/kg b.w.) showed a significant reduction in ascites tumor volume, tumor cell counts and increased median survival time (MST). EAT cells induced alterations in hematological profile and the serum marker enzymes aspartate and alanine transaminases (AST, ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were restored by DHA treatment. The antitumor effect of DHA was comparable to that of the anticancer drug cyclophosphamide suggesting the anticancer potential of the root extract of Decalepis hamiltonii.

Item Type: Article
Uncontrolled Keywords: alanine aminotransferase, alanine aminotransferase blood level, alkaline phosphatase, alkaline phosphatase blood level, animal cell, animal experiment, animal model, antineoplastic activity, antineoplastic agent, Apocynaceae, aqueous solution, article, aspartate aminotransferase, aspartate aminotransferase blood level, cancer size, cancer survival, cell count, controlled study, cyclophosphamide, Decalepis hamiltonii, Decalepis hamiltonii extract, drug isolation, Ehrlich ascites tumor, Ehrlich ascites tumor cell, hematological parameters, lactate dehydrogenase, lactate dehydrogenase blood level, male, mouse, nonhuman, plant extract, plant root, survival time, treatment response, unclassified drug
Subjects: B Life Science > Zoology
B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Department of > Zoology
Depositing User: Arshiya Kousar
Date Deposited: 21 Nov 2019 10:29
Last Modified: 21 Nov 2019 10:29
URI: http://eprints.uni-mysore.ac.in/id/eprint/9574

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