Antioxidant, anti-inflammatory, antimicrobial and cytotoxic properties of fungal endophytes from Garcinia species

Ruma, K. and Sunil, K. and Prakash, H. S. (2013) Antioxidant, anti-inflammatory, antimicrobial and cytotoxic properties of fungal endophytes from Garcinia species. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (SUPPL). pp. 889-897.

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Abstract

Objective: Fungal endophytes of medicinal plants occupy a unique habitat, highly diverse and are important sources of natural metabolites of pharmaceutical importance. Methods: The endophytes isolated from four species of Garcinia were subjected to fermentation in still culture and extracted using ethyl acetate. The crude extracts were screened for the biological activity through the assays such as antioxidant activity, 15-lipoxygenase/ human cyclooxygenase-2 inhibition, cytotoxicity, DNA nicking assay and antimicrobial activity. Results: Aspergillus fumigatus and Fusarium sp. were most promising amongst the endophytes screened from Garcinia spp. The HPLC and MS profiling of Aspergillus fumigatus anticipated the presence of the compound phloroglucinol, which could be involved in the biological activities of this extract. Conclusion: The results indicate that some of these endophytes isolated from Garcinia plants are a potential source for bioactives and could be further exploited to foster the identity of the novel molecule.

Item Type: Article
Uncontrolled Keywords: article, human, controlled study, nonhuman, 1, 1 diphenyl 2 picrylhydrazyl, antiinflammatory activity, antioxidant activity, arachidonate 15 lipoxygenase, unclassified drug, cyclooxygenase 2, antimicrobial activity, mass spectrometry, cytotoxicity, IC 50, human cell, endophyte, ultraviolet spectrophotometry, Fusarium, polyphenol, reversed phase high performance liquid chromatography, cell viability, Aspergillus fumigatus, fermentation, fungal extract, electrospray, Garcinia, Garcinia gummigutta, Garcinia indica, Garcinia morella, Garcinia xanthochymus
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Arshiya Kousar
Date Deposited: 19 Nov 2019 05:38
Last Modified: 19 Nov 2019 05:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/9570

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