Convenient synthesis of novel N-(5-allyl-7,7-difluoro)-4,5,6,7-tetrahydro- 2H-indazol-3-yl)-carboxymides

Revanna, C. N. and Raghavendra, G. M. and Nandeesh, K. N. and Bhadregowda, D. G. and Rangappa, K. S. and Mantelingu, K. (2013) Convenient synthesis of novel N-(5-allyl-7,7-difluoro)-4,5,6,7-tetrahydro- 2H-indazol-3-yl)-carboxymides. Tetrahedron Letters, 54 (38). pp. 5224-5226. ISSN 0040-4039

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5-Allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6, 7-tetrahydro-2H-pyrazolo4,3-cpyridine-3-amine represents a fluorinated heterocyclic scaffold, potentially attractive. It was synthesized via Michael addition, Mannich reaction of the difluorinated ethyl bromoacetate with a benzotriazole derivative, followed by a Dieckmann condensation. Starting from simple materials, this efficient route which gives access to novel functionalized N-(5-allyl-7,7-dihalo)-4,5,6,7-tetrahydro-2H-indazol-3-yl)- carboxymides, was explored and adapted for parallel synthesis, resulting in a compound library.

Item Type: Article
Uncontrolled Keywords: article, Mannich reaction, synthesis, Michael addition, benzotriazole derivative, bromoacetic acid, Dieckmann reaction, fluorination, indazole derivative
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 25 Nov 2019 07:09
Last Modified: 25 Nov 2019 07:09

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