Cyclocondensation of β-(aryl/heteroaryl)methylaminoenones with thionyl chloride: A facile general approach for the synthesis of 2,4-bis(het)aryl- 5(het)aroylthiazoles

Swaroop, T. R. and Ila, H. and Rangappa, K. S. (2013) Cyclocondensation of β-(aryl/heteroaryl)methylaminoenones with thionyl chloride: A facile general approach for the synthesis of 2,4-bis(het)aryl- 5(het)aroylthiazoles. Tetrahedron Letters, 54 (39). pp. 5288-5292.

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Official URL: http://doi.org/10.1016/j.tetlet.2013.07.079

Abstract

An efficient, regioselective route to 2,4-bis(het)aryl-5(het)aroylthiazoles has been developed by cyclocondensation of thionyl chloride with novel β-(het)arylmethylaminoenones which are readily accessible by the reaction of (het)arylmethylamines with 1,3-bis(het)arylmonothio-1,3-diketones. The method allows entry to 2,4,5-trisubstituted thiazoles, with full control for the introduction of either a (het)aryl group at 2,4 positions or a (het)aroyl group at 5 position of the thiazole ring.

Item Type: Article
Uncontrolled Keywords: article, unclassified drug, chemical structure, synthesis, chloride, thiazole derivative, chemical modification, cyclocondensation, methylamine, methylaminoenone derivative, thiopental
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 21 Nov 2019 11:42
Last Modified: 21 Nov 2019 11:42
URI: http://eprints.uni-mysore.ac.in/id/eprint/9560

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