Synthesis and antimicrobial evaluation of novel derivatives of 1,3,4-thiadiazine incorporated with pyrazole-4-carboxylic acid moiety

Shubakar, K. and Umesha, K. B. and Srikantamurthy, N. and Chethan, J. (2013) Synthesis and antimicrobial evaluation of novel derivatives of 1,3,4-thiadiazine incorporated with pyrazole-4-carboxylic acid moiety. Bulgarian Chemical Communications, 45 (3). pp. 274-279.

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Abstract

2-Amino-5-phenyl-6H-1,3,4-thiadiazine (5a-c) condense with pyrazole-4-carboxylate (1a-e) using alcohol as a solvent to give 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid-(5-phenyl-6H-1,3,4- thiadiazin-2-yl)-amide (6ai) in 30\% yield. The same product is obtained from pyrazole-4-acid (2a-e) in presence of HOBt (1-hydroxybenzotriazole) and EDC (N-ethyl-N'-(3-dimethyl-aminopropyl)-carbodiimide hydrochloride) in triethyl amine using CHCl3 as a solvent, in 75-85\% yields. The structures of these compounds (6a-i) were characterized by FT-IR, 1H NMR, mass spectroscopic techniques and elemental analysis. All synthesized pyrazole-1,3,4-thiadiazine (6a-i) derivatives were found to exhibit antimicrobial activities.

Item Type: Article
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Divisions: Department of > Biotechnology
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 10 Dec 2019 07:44
Last Modified: 10 Dec 2019 07:44
URI: http://eprints.uni-mysore.ac.in/id/eprint/9546

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