Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with Developmental Dyslexia

Venkatesh, S. K. and Siddaiah, A. and Padakannaya, P. and Ramachandra, N. B. (2013) Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with Developmental Dyslexia. Gene, 529 (2). pp. 215-219.

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Official URL: http://doi.org/10.1016/j.gene.2013.08.017

Abstract

Developmental Dyslexia (DD) is a heritable, complex genetic disorder characterized by specific impairment in reading and writing ability that is substantially below the expected reading ability given the person's chronological age, measured intelligence and age-appropriate education. More than ten susceptible genes have been identified for DD. A Single Nucleotide Polymorphism (SNP) of these genes was found to be associated with various phenotypes of DD. To identify the role of SNPs of four candidate genes namely, MRPL19/. C2ORF3, ROBO1 and THEM2 in an Indian population, we genotyped eight SNPs of these genes in 157 children with DD and 212 normal readers using a MassARRAY technique with a MALDI-TOF MS analyzer. Power analysis of some of these SNPs showed \textgreater. 80% of power. Chi-square test, Odds Ratios (ORs), 95% Confidence Intervals (CIs) and Bonferroni's correction were applied to identify the significance of the genotyped SNPs and haplotypes. Our study failed to show any association of SNPs and haplotypes of these genes with DD in an Indian population.

Item Type: Article
Uncontrolled Keywords: adolescent, Adolescent, adult, article, c2orf3 protein, Candidate genes, Case-control, Case-Control Studies, child, Child, CI, Confidence Intervals, controlled study, DD, developmental disorder, developmental dyslexia, Developmental Dyslexia, dyslexia, Dyslexia, Female, fMRI, functional Magnetic Resonance Imaging, gene, genetic association, Genetic Association Studies, genetic variability, genotype, haplotype, Haplotypes, Hardy-Weinberg Equilibrium, human, Humans, HWE, Immunologic, Indian, MAF, major clinical study, MALDI-TOF MS, Male, MassARRAY, matrix assisted laser desorption ionization time of flight mass spectrometry, Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry, membrane protein, Minor Allele Frequency, Mitochondrial Proteins, mrpl19 protein, Nerve Tissue Proteins, Odds Ratio, OR, Polymorphism, power analysis, priority journal, Receptors, Ribosomal Proteins, robo1 protein, school child, Single Nucleotide, single nucleotide polymorphism, Single Nucleotide Polymorphisms, SNPs, Speech-Sound Disorder, SPM, SSD, Standard Progressive Matrices, them2 protein, Thiolester Hydrolases, unclassified drug
Subjects: A Arts and Humanities > Psychology
B Life Science > Zoology
Divisions: Department of > Psychology
Department of > Zoology
Depositing User: Arshiya Kousar
Date Deposited: 10 Dec 2019 07:43
Last Modified: 10 Dec 2019 07:43
URI: http://eprints.uni-mysore.ac.in/id/eprint/9538

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