Rapid spectophotometric determination of sulphonamide derivatives with resorcinol

Nagaraja, P. and Sunitha, K. R. and Vasantha, R. A. and Yathirajan, H. S. (2002) Rapid spectophotometric determination of sulphonamide derivatives with resorcinol. Indian journal of pharmaceutical sciences, 64 (4). p. 391. ISSN 1998-3743

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A rapid and simple spectrophotometric method for the determination of sulpha drugs is described. The method is based on the formation of a red coloured azo product by the diazotisation of sulphonamides, sulphamethoxazole, sulphadiazene and sulphacetamide followed by a coupling reaction with resorcinol. Absorbance of the resulting red azo product is measured at 500 nm. Beer's law is obeyed in the concentration range of 0.25-7.0 µg/ml at the wavelength of maximum absorption. The method is successfully employed for the determination of sulphonamides in various pharmaceutical preparations.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 18 Oct 2019 10:14
Last Modified: 18 Oct 2019 10:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/9297

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