Synthesis and antimicrobial activity of novel isoxazolines by 1, 3-dipolar cycloaddition reactions

Govindaraju, M. and Vasanth Kumar, G. and Ajay, K. (2014) Synthesis and antimicrobial activity of novel isoxazolines by 1, 3-dipolar cycloaddition reactions. International Journal of ChemTech Research, 6 (2). pp. 886-890. ISSN 0974-4290

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Abstract

Nitrile oxides were generated by the catalytic dehydrogenation of aromatic aldehyde oximes 2a-g with chloramine-T as oxidizing agent. The 1,3-dipolar cycloaddition of in situ generated nitrile oxides with ethyl oleate 1 produced a series of new ethyl 8-(3-aryl-4-octyl-4,5-dihydroisoxazol-5-yl)octanoate 3a-g in 65- 84 yield. Some of the synthesized cycloadducts have exhibited moderate to good antifungal and antibacterial activity.

Item Type: Article
Uncontrolled Keywords: Cycloaddition and Dipolar and Isoxazolines and Antifungal and Antibacterial and MIC's.
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Users 19 not found.
Date Deposited: 18 Oct 2019 09:54
Last Modified: 16 Jul 2022 07:05
URI: http://eprints.uni-mysore.ac.in/id/eprint/9290

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