Synthesis and antimicrobial study of new 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphtho[1,2e][1,3]oxazines

Mayekar, Anil and Yathirajan, H. S. and Narayana, B. and Sarojini, B. K. and Nalilu Suchetha Kumari and Harrison, William (2011) Synthesis and antimicrobial study of new 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphtho[1,2e][1,3]oxazines. International Journal of Chemistry, 3 (1). ISSN 1916-9701

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A series of new 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphth[1,2e][1,3]oxazines 2a-n are synthesized. 6-Bromonaphthol undergoes ring closure reaction with substituted aryl and heteroarylaldehydes to give naphthoxazine derivatives. Some of these are hydrolyzed to obtain aminobenzylnaphthols 3c,l which are further condensed with different aryl/heteroaldehydes to yield 4a-e. The structures of newly synthesized compounds are confirmed through elemental analysis, spectral studies and single crystal X-ray study. Compounds are screened for their antibacterial and antifungal activity. Some of them exhibited promising activity.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 17 Oct 2019 09:45
Last Modified: 17 Oct 2019 09:45

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