Novel 4-methoxy-2-acetyl benzofuran based chalcones: A new perceptivity into their antioxidant potentials

Naik, N. and Vijay Kumar, H. and Dias, S. M. and Ranga Swamy, J. (2013) Novel 4-methoxy-2-acetyl benzofuran based chalcones: A new perceptivity into their antioxidant potentials. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (1). pp. 242-247. ISSN 0975-1491

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Abstract

A new series of 4-methoxy-2-acetyl benzofuran based chalcones (2a-i) were synthesized by aldol base condensation reaction. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis and were evaluated for their antioxidant potential using various in vitro assays like 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, microsomal lipid peroxidation inhibition (LPO) assay and ferric reducing power assay. Butylated hydroxy anisole (BHA) was used as a reference compound and the comparative study with the newly synthesized compounds was also performed. All the newly synthesized analogues showed certain degree of antioxidant activity, among the entire synthesized analogues compound (2h) bearing electron donating hydroxy and methoxy group on the phenyl moiety showed predominant activity and exhibits even more activity than the standard.

Item Type:	Article
Uncontrolled Keywords:	1, 1 (4 methoxybenzofuran 2 yl) 3 (2 methoxyphenyl)prop 2 en 1 one, 1 (4 methoxybenzofuran 2 yl) 3 (4 nitrophenyl)prop 2 en 1 one, 1 (4 methoxybenzofuran 2 yl) 3 p tolylprop 2 en 1 one, 1 (4 methoxybenzofuran 2 yl) 3 phenylprop 2 en 1 one, 1 diphenyl 2 picrylhydrazyl, 3 (2 hydroxy 3 methoxyphenyl) 1 (4 methoxybenzofuran 2 yl) prop 2 en 1 one, 3 (2 hydroxyphenyl) 1 (4 methoxybenzofuran 2 yl)prop 2 en 1 one, 3 (3, 3 (4 chlorophenyl) 1 (4 methoxybenzofuran 2 yl)prop 2 en 1 one, 3 (4 hydroxyphenyl) 1 (4 methoxybenzofuran 2 yl)prop 2 en 1 one, 4 dimethoxyphenyl) 1 (4 methoxybenzofuran 2 yl) prop 2 en 1 one, 4 methoxy 2 acetyl benzofuran chalcone, antioxidant activity, article, carbon nuclear magnetic resonance, chalcone derivative, controlled study, drug synthesis, infrared spectrometry, lipid peroxidation, proton nuclear magnetic resonance, unclassified drug
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	18 Oct 2019 07:24
Last Modified:	18 Oct 2019 07:24
URI:	http://eprints.uni-mysore.ac.in/id/eprint/9189

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