Novel synthesis of 4,4-difluoropyrido[4,3-b]indoles via intramolecular Heck reaction

Madaiah, M. and Prashanth, M. K. and Revanasiddappa, H. D. (2013) Novel synthesis of 4,4-difluoropyrido[4,3-b]indoles via intramolecular Heck reaction. Tetrahedron Letters, 54 (11). pp. 1424-1427. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2012.12.115

Abstract

Various difluoropyridoindoles were synthesized via a palladium-catalyzed intramolecular Heck reaction as a key step. Thus, ortho-bromoanilines and difluoropiperidinone were treated with (PPh3)2PdCl 2 and base in pyridine to give the regioselective cyclized heterocycles in modest to satisfactory yields.

Item Type: Article
Uncontrolled Keywords: article, unclassified drug, 4, synthesis, catalysis, ketone, indole derivative, palladium, 1 (6, 2 b]pyran 7 yl) 2 piperidinone, 2 bromoaniline derivative, 3 b]indole derivative, 4 difluoropyrid4, 5 dimethyl 2 nitro 5h thieno3, 7 dihydro 6 hydroxy 5, aniline, cross coupling reaction, difluoropiperidinone, Heck reaction
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 17 Oct 2019 09:37
Last Modified: 17 Oct 2019 09:43
URI: http://eprints.uni-mysore.ac.in/id/eprint/9188

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