Permaganometric determination of sumatriptan succinate in pure drug and pharmaceutical formulation

Prashanth, K. N. and Basavaiah, K. and Raghu, M. S. (2013) Permaganometric determination of sumatriptan succinate in pure drug and pharmaceutical formulation. Thai Journal of Pharmaceutical Sciences, 37 (2). pp. 95-106.

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Based on the reduction of permanganate by sumatriptan succinate (STS) in acidic medium, two simple, sensitive and cost-effective methods were described for the determination of STS in bulk drug and in formulation. In titrimetry (method A), STS was oxidized by a known excess of potassium permanganate (KMnO4) in H2SO4 medium followed by determination of unreacted permanganate by titration with ferrous ammonium sulphate. In spectrophotometry (method B), STS was treated with a measured excess of permanganate in acid medium and the unreacted oxidant was measured at 545 nm. The molar combining ratio in titrimetry and the optimum assay conditions were studied. Titrimetry was applicable over 1-7 mg range and the calculations were based on a 1:6 (STS: KMnO4) molar ratio. In spectrophotometry, Beerûs law was obeyed over 0.8-16.0 μg ml-1 concentration range of STS. The molar absorptivity and Sandell sensitivity values are calculated to be 1.39 � 104 l mol-1 cm-1 and 0.03 μg cm-2, respectively. The limits of detection (LOD) and quantification (LOQ) were also reported for the spectrophotometric method. The applicability of the developed methods was demonstrated by the determination of STS in pure drug as well as in commercial dosage form.

Item Type: Article
Uncontrolled Keywords: accuracy, acid, ammonium sulfate, article, chemical analysis, concentration response, cost effectiveness analysis, drug determination, drug formulation, drug purification, drug selectivity, drug sensitivity, drug structure, ferrous ammonium sulfate, limit of detection, limit of quantitation, oxidizing agent, permaganometry, permanganate potassium, pH, process optimization, spectrophotometry, sulfuric acid, sumatriptan succinate, suminat, titrimetry, unclassified drug
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 19 Oct 2019 06:17
Last Modified: 19 Oct 2019 06:17

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