Mostafa, A. and Sudisha, J. and El-Sayed, M. and Ito, S. I. and Ikeda, T. and Yamauchi, N. and Shigyo, M. (2013) Aginoside saponin, a potent antifungal compound, and secondary metabolite analyses from Allium nigrum L. Phytochemistry Letters, 6 (2). pp. 274-280.
Full text not available from this repository. (Request a copy)Abstract
The HPLC and spectral analyses of cysteine sulfoxides (CSOs), total polyphenols (TP), and total saponins revealed quantitative variations within the different organs of Allium nigrum L. A large accumulation of CSOs was detected in the bulb (0.367 mg/g fw), of TP in the leaf (116.05 mg CE/100 g fw), and of saponins in the root (19.38 mg/g dw). Phytochemical and chromatographical investigations of A. nigrum root extract led to the isolation of a spirostane-type glycoside or aginoside. The structure was elucidated by spectroscopic analysis (2D NMR, FABMS, HR-ESI-MS). The structure of the aginoside was identified as 25(R,S)-5α-spirostan-2α,3β,6β-trio1-3-O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside. The highest content of aginoside, 2.9 mg/g dw, was detected in the root. The in vitro and in vivo antifungal activity of aginoside was evaluated for the first time against phytopathogens. This compound showed significant (P < 0.05) antifungal activity depending on the concentration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aginoside saponin, Allium nigrum, antifungal activity, antifungal agent, article, drug metabolite, glycoside, high performance liquid chromatography, in vitro study, in vivo study, medicinal plant, nonhuman, plant bulb, plant leaf, plant root, plant stem, priority journal, saponin, unclassified drug |
| Subjects: | B Life Science > Biotechnology |
| Divisions: | Department of > Biotechnology |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 18 Oct 2019 09:12 |
| Last Modified: | 18 Oct 2019 09:12 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/9172 |
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