Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: Synthesis and pharmacological screening

Ningaiah, S. and Bhadraiah, U. K. and Keshavamurthy, S. and Javarasetty, C. (2013) Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: Synthesis and pharmacological screening. Bioorganic and Medicinal Chemistry Letters, 23 (16). pp. 4532-4539. ISSN 0960-894X

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Official URL: https://doi.org/10.1016/j.bmcl.2013.06.042

Abstract

A novel series of pyrazoline amidoxime (2a-d) and pyrazoly-1,2,4-oxadiazole (3a-p) and (4) of pharmacological significance have been synthesised. Structures of newly synthesised compounds were characterized by spectral studies. New compounds were screened for their in vitro antioxidant, antimicrobial and antiinflammatory activities. Among the synthesized compounds, compound 2a, 3l and 3o were found to be active antimicrobial agents in addition to having potent antioxidant activity, while the compound 3f showed promising antiinflammatory activity in comparison with standard drug.

Item Type: Article
Uncontrolled Keywords: article, controlled study, drug screening, nonhuman, antiinflammatory activity, antioxidant activity, lipid peroxidation, infrared spectroscopy, drug structure, antioxidant, Antioxidants, antifungal activity, Aspergillus flavus, Aspergillus niger, drug synthesis, Escherichia coli, Staphylococcus aureus, in vitro study, Fungi, antifungal agent, antimicrobial activity, fluconazole, Molecular Structure, Oximes, Anti-Infective Agents, Bacteria, antibiotic agent, chloramphenicol, Amides, proton nuclear magnetic resonance, Anti-Inflammatory Agents, antiinflammatory agent, drug design, Antioxidant, Bacillus cereus, Drug Evaluation, Preclinical, Pyrazoles, pyrazoline derivative, Klebsiella pneumoniae, Shigella flexneri, Biological Assay, Oxadiazoles, Amidoxime, Antimicrobial, oxadiazole derivative, Antiinflammatory, Bis-heterocycles, EDC·HCl, Fatty Acids
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 22 Oct 2019 05:19
Last Modified: 22 Oct 2019 05:19
URI: http://eprints.uni-mysore.ac.in/id/eprint/9127

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