Synthesis of N-5-aryl-1,3,4-oxadiazole-2-ylmethyl-4-methoxyaniline derivatives and their anticonvulsant activity

Prasanna Kumar, B. N. and Mohana, K. N. and Mallesha, L. (2013) Synthesis of N-5-aryl-1,3,4-oxadiazole-2-ylmethyl-4-methoxyaniline derivatives and their anticonvulsant activity. Journal of Chemistry.

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Official URL: http://doi.org/10.1155/2013/121029

Abstract

A series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4(a-i) have been conveniently synthesized by intramolecular oxidative cyclization of (E)-2-(arylbenzylidene)-2-(4-methoxyphenyl)aminoacetohydrazides promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds have been confirmed by 1H and 13C NMR, IR, MS, and elemental analysis. All the newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Compounds 4g, 4d, and 4a were found to be the most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered. © 2013 B. N. Prasanna Kumar et al.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 21 Oct 2019 11:51
Last Modified: 21 Oct 2019 11:51
URI: http://eprints.uni-mysore.ac.in/id/eprint/9126

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