In vitro comparative study of membrane stabilization capacity of different extracts of blepharis maderaspatensis (l.) heyne ex roth. and blepharis molluginifolia pers. grown in the region of Mysore, Karnataka

Neelambika, H. S. and Leelavathi, S. (2014) In vitro comparative study of membrane stabilization capacity of different extracts of blepharis maderaspatensis (l.) heyne ex roth. and blepharis molluginifolia pers. grown in the region of Mysore, Karnataka. International Journal of Pharmaceutical Sciences and Research, 5 (7). pp. 2698-2702. ISSN 0975-8232

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Abstract

Blepharis is a genus belonging to family Acanthaceae. It is an Afro-asiatic genus comprising 129 species which occur in arid and semi-arid habitats. They are used for the treatment of a number of ailments. Anti-inflammatory activity was performed based on the folk lore information. The present study is aimed at the evaluation of anti-inflammatory property of the petroleum ether, ethyl acetate and ethanolic extracts of Blepharis maderaspatensis (L.) Heyne ex Roth. and Blepharis molluginifolia Pers. whole plant by using Human red blood cell (HRBC) membrane stabilization method. Ibuprofen is used as reference drug for comparison. HRBC method was selected for the in vitro evaluation of anti-inflammatory property because the erythrocyte membrane is analogous to the lysosomal membrane and its stabilization implies that the extract may as well stabilize lysosomal membranes. The results revealed that both Blepharis maderaspatensis (L.) Heyne ex Roth. and Blepharis molluginifolia Pers. have anti-inflammatory activity. Among the test samples tested for membrane stabilization, Blepharis maderaspatensis ethyl acetate extract showed better membrane stability with 323.3±15.7 IC50 (ìg/ml), followed by with same plant alcoholic extract with 377.6±21.3 IC50 (ìg/ml). The result of the present study authenticates the folk lore information on the anti-inflammatory properties of the above plants.

Item Type: Article
Uncontrolled Keywords: Blepharis Maderaspatensis (L.) Heyne Ex Roth. and Blepharis Molluginifolia Pers. and HRBC Method and In Vitro Anti Inflammatory Studies
Subjects: B Life Science > Botany
Divisions: Department of > Botany
Depositing User: Shrirekha N
Date Deposited: 14 Oct 2019 09:33
Last Modified: 14 Oct 2019 09:33
URI: http://eprints.uni-mysore.ac.in/id/eprint/9018

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