Synthesis, characterization and biological evaluation of functionalized derivatives of versatile synthon 4, 4'-difluoro chalcone

Samshuddin, S. and Narayana, B. and Sarojini, B. K. and Yathirajan, H. S. and Raghavendra, R. (2012) Synthesis, characterization and biological evaluation of functionalized derivatives of versatile synthon 4, 4'-difluoro chalcone. Der Pharma Chemica, 4 (4). pp. 1445-1457. ISSN 0975-413X

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Abstract

Some functionalized fluorinated derivatives are prepared by condensing 4, 4'-difluoro chalcone with hydrazine derivatives, o-phenylenediamine, ammonium acetate/acetic acid, ethyl cyanoacetate, malononitrile, acetylacetone, esters of acetoacetic acid, acetoacetanilde, aminoguanidine hydrochloride, urea and thiourea. All these derivatives are characterized by NMR, IR, mass spectral and also some of them by single crystal XRD data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. Majority of the tested compounds exhibited significant antimicrobial activity and some of them showed DPPH scavenging activity.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 14 Oct 2019 06:34
Last Modified: 14 Oct 2019 06:34
URI: http://eprints.uni-mysore.ac.in/id/eprint/9004

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