Genetic epidemiology studies on unusual genetic morphophenotypes in a settled community from South India

Avinash, V. M. and Archana, S. and Latha, S. and Madhumala, S. and Shivaprasad, S. and Swarna, M. (2014) Genetic epidemiology studies on unusual genetic morphophenotypes in a settled community from South India. Recent Advances in Biology and Medicine, 1. pp. 1-6. ISSN 2378-654X

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Official URL: https://doi.org/10.18639/RABM.2014.01.59897

Abstract

Genetic disorders in a population can be caused in many ways and these genetic disorders are heritable, and are passed down the generations. These disorders are complex, multifactorial, or polygenic, and are associated with the effects of multiple genes in combination with lifestyles and environmental factors. Familial aggregation approach and segregation approach was used in this study to identify the prevalent genetic conditions and their inheritance patterns. Here, we report a population which had a very high number of unusual genetic morphophenotypes. We observed that these unusual morphophenotypes in this population are a result of an interaction between “inbreeding, consanguinity and accumulating mutations”. Statistical analysis revealed that individuals in this population carry more than 20 deleterious recessive genes based on Slatis method of calculating abnormal autosomal recessive genes in individuals.

Item Type: Article
Uncontrolled Keywords: Genetic Disorders and Consanguinity and Genetic Epidemiology
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: Shrirekha N
Date Deposited: 14 Oct 2019 06:26
Last Modified: 14 Oct 2019 06:26
URI: http://eprints.uni-mysore.ac.in/id/eprint/9003

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