Antimicrobial evaluation of 2-azetidinonyl 5-(2-benzoyl-phenoxymethyl)-1, 3, 4-oxadiazole derivatives

Lakshmi Ranganatha, V. and Al-Ghorbani, M. and Naveen, P. and Bushra Begum, A. and Prashanth, T. and Shaukath Ara Khanum (2013) Antimicrobial evaluation of 2-azetidinonyl 5-(2-benzoyl-phenoxymethyl)-1, 3, 4-oxadiazole derivatives. Der Pharma Chemica, 5 (4). pp. 240-243. ISSN 0975-413X

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Benzophenone and their derivatives are important and useful compounds with diverse pharmacological properties. In the present study, we have evaluated the in vitro antibacterial activity of new 2-azetidinonyl-5-(2-benzoylphenoxymethyl)-1, 3, 4-oxadiazole derivatives 6a-j using Gram positive and Gram negative bacterial strains. Minimal inhibitory concentrations (MIC) were determined in order to monitor the efficacy of the synthesized compounds. Certain compounds inhibit bacterial growth with low MIC (mg/mL) value. The most potent antibacterial compounds of this series were compounds 6a, 6d and 6g which have lower MIC value of 4.68 mg/ml in selected strains.

Item Type: Article
Uncontrolled Keywords: 1, 2 azetidinonyl 5 (2 benzoyl phenoxymethyl) 1, 3, 4 oxadiazole derivative, antibacterial activity, article, Bacillus cereus, Bacillus subtilis, bacterial growth, bacterial strain, concentration response, drug screening, drug structure, drug synthesis, Enterobacter aerogenes, Escherichia coli, growth inhibition, in vitro study, Klebsiella pneumoniae, methicillin resistant Staphylococcus aureus, Micrococcus luteus, minimum inhibitory concentration, nonhuman, Palinurus vulgaris, Pseudomonas aeruginosa, Salmonella paratyphi B, Salmonella typhimurium, Staphylococcus aureus, streptomycin, unclassified drug
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 15 Oct 2019 06:13
Last Modified: 15 Oct 2019 06:13

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