Synthesis and larvicidal properties of benzophenone comprise indole analogues against Culex quinquefasciatus

Lakshmi Ranganatha, V. and Bushra Begum, A. and Prashanth, T. and Gurupadaswamy, H. D. and Madhu, S. K. and Shivakumar, S. and Shaukath Ara Khanum (2013) Synthesis and larvicidal properties of benzophenone comprise indole analogues against Culex quinquefasciatus. Drug Invention Today, 5 (4). pp. 275-280. ISSN 0975-7619

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Official URL: http://doi.org/10.1016/j.dit.2013.10.001

Abstract

With the increase of resistance to conventionally used existing synthetic insecticides, vector management has become extremely challenging. Hence more attention has been focused on newly synthesized benzophenone integrated indole analogues. Therefore our present study was aimed to evaluate the efficacy of synthesized benzophenone integrated indoles against the larvae of filariasis vector mosquitoes, Culex quinquefasciatus employing standard WHO procedure at Mysore. Among all the synthesized compounds the efficacy of compounds 7a, 7b and 7j seemed to be efficient with LC50 values of 9.17, 3.93 and 1.63ppm respectively and LC90 values of 24.17, 8.85 and 6.17ppm respectively. From the results, compounds 7a, 7b and 7j seemed could be considered as powerful candidates to bring about useful synthetic insecticides so as to prevent the resurgence of mosquito vectors.

Item Type: Article
Uncontrolled Keywords: (5 bromo n indol 3 yl)acetic acid 4 benzoyl 2 methylphenyl ester derivative, article, benzophenone derivative, controlled study, Culex quinquefasciatus, insecticidal activity, larval stage, larvicidal agent, LC 50, nonhuman, structure analysis, synthesis, unclassified drug, vector control
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Divisions: Department of > Biotechnology
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 16 Oct 2019 09:38
Last Modified: 16 Oct 2019 09:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/8962

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