Jahromi, Sareh Raeiszadeh and Mahesh, P. A. and Jayaraj, B. S. and Madhunapantula, Subba Rao V. and Amrutha, D. Holla and Sangeetha, V. and Ramachandra, N. B. (2014) Serum levels of IL-10, IL-17F and IL-33 in patients with asthma: a case–control study. Journal of Asthma, 51 (10). pp. 1004-1013. ISSN 1532-4303
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AbstractObjectives: The development of inflammation in asthma involves an intricate network of cytokines that recruit and activate numerous immune cells. This study was aimed to compare serum levels of IL-10, IL-17F, and IL-33 in asthmatic patients and non-asthmatic controls and correlate cytokine levels to asthma severity and various clinical, spirometric, and laboratory variables. Methods: Using ELISA, serum levels of IL-10, IL-17F, and IL-33 were evaluated in 44 asthmatics (14 mild persistent, 15 moderate persistent, and 15 severe persistent) and 44 controls. Results: This is one of the first reports showing a significant difference in serum levels of asthma-associated cytokines, anti-inflammatory IL-10, and pro-inflammatory IL-17F and IL-33, in the same subset of asthmatic patients. Our results showed diminished level of IL-10 and elevated levels of IL-17F and IL-33 in asthmatics than in controls (p < 0.001). Assessment of cytokine levels between subjects of different gender, age group, and BMI showed non-significant differences. Correlation analysis of cytokine levels to clinical variables showed that IL-17F is associated negatively to FVC % predicted (forced vital capacity) and FEV1% predicted (forced expiratory volume in one second) and positively to number of allergens sensitized and FEV1 reversibility. A strong negative correlation was found between IL-10 and IL-33 levels (p = 0.001). Conclusions: Negative correlation between IL-10 and IL-33 levels may reflect a converse relationship between anti-inflammatory and pro-inflammatory cytokines in an individually balanced pattern. The association between IL-17F level and asthmatic phenotypes such as reduced FVC and FEV1, higher degree of sensitization, and post-bronchodilator reversibility needs further assessments.
| Item Type: | Article |
|---|---|
| Subjects: | B Life Science > Genetics and Genomics |
| Divisions: | Department of > Genetics and Genomics |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 11 Oct 2019 05:09 |
| Last Modified: | 10 Dec 2020 10:09 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8879 |
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