Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha)

Girish, K. S. and Machiah, K. D. and Usha Nandini, S. and Harish Kumar, K. and Nagaraju, S. and Govindappa, M. and Vedavathi, M. and Kemparaju, K. (2006) Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha). JOURNAL OF BASIC MICROBIOLOGY, 46 (5). pp. 365-374.

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Official URL: http://dx.doi.org/10.1002/jobm.200510108

Abstract

A monomeric glycoprotein with a molecular mass of 28 kDa in SDS-PAGE was isolated from the Withania somnifera root tubers. The protein designated WSG (Withania somnifera glycoprotein) demonstrated potent antimicrobial activity against the phytopathogenic fungi and bacteria tested. Antifungal effect has been demonstrated in that WSG exerts a fungistastic effect by inhibiting spore germination and hyphal growth in the tested fungi. WSG showed potent antifungal activity against Aspergillus flavus, Fusarium oxysporum, F. verticilloides and antibacterial activity against Clvibacter michiganensis subsp. michiganensis. WSG is an acidic, non-toxic (trypsin-chymotrypsin) protease inhibitor. These results encourage further studies of WSG as a potential therapeutic agent for its antifungal activity.

Item Type: Article
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry

Agriculture Biological Sciences > Biotechnology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biotechnology
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
PG Campuses > Manasagangotri, Mysore > Biotechnology
Depositing User: Users 17 not found.
Date Deposited: 07 May 2013 07:15
Last Modified: 30 Nov 2015 05:40
URI: http://eprints.uni-mysore.ac.in/id/eprint/8800

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