Synthesis and study of antimitotic activity of new tetralone esters

Krishna, M. H. and Umesha, B. and Shivakumar, S. B. and Basavaiah, Y. (2014) Synthesis and study of antimitotic activity of new tetralone esters. International Journal of Chemical and Pharmaceutical Sciences, 5 (3). pp. 105-111. ISSN 0976-9390

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Podophyllotoxin is a natural product isolated from two important medicinal plants podophyllum emodi and podophyllum peltatum. Its semi synthetic derivatives etoposide (VP-16) and teniposide (VM-26) are currently in clinical use in the treatment of many cancers, particularly small cell lung carcinoma (SCLC), malignant lymphoma and testicular cancer. In addition podophyllotoxin exhibits strong antimitotic, antiAIDS, antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues are synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained are characterized by spectral and elemental analysis data. The antimitotic activities of all the synthesized new tetralone esters are determined by onion-root tip method.

Item Type: Article
Uncontrolled Keywords: Friedel-Crafts Acylation and Claisen-Schmidt Reaction and Ethyl Chloroacetate and Anhyd and Stannic Chloride and Tetralone Esters and Antimitotic Activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 19 not found.
Date Deposited: 09 Oct 2019 10:09
Last Modified: 09 Oct 2019 10:09

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