Synthesis of new substituted tetralone acids and evaluation of antimitotic activity

Shivakumar, S. B. and Umesha, B. and Krishna, M. H. and Basavaiah, Y. (2014) Synthesis of new substituted tetralone acids and evaluation of antimitotic activity. International Journal of Chemical and Pharmaceutical Sciences, 5 (3). pp. 65-71. ISSN 0976-9390

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Abstract

The novel substituted tetralone acids analogues of podophyllotoxin were synthesized in high yields by Genslers method with some modification in reagents and experimental procedure. The structure of the compounds was confirmed by analytical and spectral data. The synthesized new compounds were evaluated for their antimitotic activity by onion root tip method. Analogues synthesized in the present work showed strong to moderate activity. The antimitotic activity was compared with control, compound 7d showed more potent inhibition and compound 7b and 7c exhibited less inhibition while 7a exhibited moderate activity.

Item Type: Article
Uncontrolled Keywords: Ketones and Stobbe Condensation and Catalytic Hydrogenation and Antimitotic Activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 19 not found.
Date Deposited: 09 Oct 2019 10:02
Last Modified: 09 Oct 2019 10:02
URI: http://eprints.uni-mysore.ac.in/id/eprint/8795

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