Biological activities of synthetic pyrimidine derivatives

Sathisha, K. R. and Shubha Gopal and Rangappa, K. S. (2016) Biological activities of synthetic pyrimidine derivatives. World Journal of Pharmaceutical Research, 5 (2). pp. 1467-1491. ISSN 2277– 7105

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Abstract

Heterocyclic chemistry is a rapidly expanding branch of organic chemistry. Nitrogen, sulphur and oxygen are the most common heteroatoms present in the heterocyclic ring. Nitrogen containing heterocycles are widely distributed in nature and are the constituents of diverse group of essential molecules from antibiotics to vitamins and are a vital part of nucleic acids. Literature survey indicated that pyrimidine derivatives have a wide range of pharmacological activities making them popular candidates for drug discovery protocols. Synthetic derivatives of pyrimidines have been shown to have antihyperuricemic, anti cancer, anti-inflammatory, antibacterial, antifungal, antiviral, antioxidant, anticonvulsant, anti tubercular, antibiotic, analgesic, antipyretic, antihypertensive, antihistaminic, antiallergic, antileishmanial, antidiabetic, herbicidal, central nervous system depressant, and calcium channel blocking activities to name a few. Pyrimidine derivatives will continue to be a source of new drugs to treat the ever increasing burden of diseases. Some of the important biological activities are described in this review.

Item Type: Article
Subjects: B Life Science > Microbiology
C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Department of > Microbiology
Depositing User: Arshiya Kousar
Date Deposited: 05 Oct 2019 07:08
Last Modified: 05 Oct 2019 07:08
URI: http://eprints.uni-mysore.ac.in/id/eprint/8754

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