Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine derivatives by Suzuki coupling: as Acetyl Cholinesterase inhibitors

Benaka Prasad, S. B. and Sunil Kumar, Y. C. and Ananda Kumar, C. S. and Sadashiva, C. T. and Vinaya, K. and Rangappa, K. S. (2007) Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine derivatives by Suzuki coupling: as Acetyl Cholinesterase inhibitors. The Open Medicinal Chemistry Journal, 1. pp. 4-10. ISSN 1874-1045

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising therapeutic approach for the treatment of AD. Thus, providing a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of Acetylcholinesterase (AChE) inhibitors. In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	30 Sep 2019 05:06
Last Modified:	30 Sep 2019 05:06
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8626

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